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Galactose regulon of yeast from genetics to systems biology by Paike Jayadeva Bhat

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Published by Springer in Berlin .
Written in English


  • Galactose -- genetics,
  • Regulon -- genetics,
  • Yeasts,
  • Galactose,
  • Yeast fungi -- Molecular genetics

Book details:

Edition Notes

Includes bibliographical references and index.

StatementPaike Jayadeva Bhat.
LC ClassificationsQD321 .B48 2008
The Physical Object
Paginationxiv, 219 p. :
Number of Pages219
ID Numbers
Open LibraryOL16864889M
ISBN 103540740147, 3540740155
ISBN 109783540740148, 9783540740155
LC Control Number2007937224

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The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in Our Stores Are Open Book Annex Membership Educators Gift Cards Stores & Events HelpPrice: $ The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. Galactose Regulon Of Yeast by Iva Sebesta - Issuu Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, . Description: This self contained book presents a comprehensive overview of the past, present and future of the galactose regulon of yeast, the classical model system of molecular biologists. The book starts with a brief historical overview on yeast research.

  One of the best studied native regulons is the galactose (GAL) system in the yeast Saccharomyces cerevisiae (S. cerevisiae), where Gal3p-mediated sugar detection initiates a genome-wide response. Guide to Yeast Genetics and Molecular Biology presents, for the first time, a comprehensive compilation of the protocols and procedures that have made Saccharomyces cerevisiae such a facile system for all researchers in molecular and cell biology. Whether you are an established yeast biologist or a newcomer to the field, this volume contains all the up-to-date methods you .   Galactose activates several feedback loops once transported into the cytosol. The other important sugar in yeast is raffinose, a trisaccharide composed of fructose, glucose and galactose. With respect to the galactose network, raffinose and glycerol neither activate, nor inhibit the galactose network, as galactose and glucose do, respectively. Transcriptional regulation in the galactose regulon of yeast is determined by an interplay between a positive regulatory protein, GAL4, and a negative regulatory protein, GAL We show that derivatives of GAL4 missing as few as 28 carboxy-terminal amino acids are not responsive to GAL80 regulation, implying that the carboxyl terminus of GAL4 is required for interaction with .

  The galactose/melibiose (GAL/MEL) regulon of Saccharomyces cerevisiae is one of the best characterized eukaryotic systems of transcriptional regulation. The structural genes of this regulon, the GAL genes, are regulated at the level of transcription in a carbon source‐dependent manner (Johnston and Carlson, ; Lohr et al., ). Galactose utilization is respiration dependent in K. lactis. Galactose utilization in K. lactis, as in S. cerevisiae, is a galactose-inducible activity. Most of the galactose regulon genes are equivalent in the two species (10, 39, 45). Galactose is first taken up by a permease, which in S. cerevisiae is encoded by GAL2 (29, 36). The lactose/galactose regulon of K. lactis, which is regulated by the prototypic transcription activator Gal4 exemplifies important aspects of network evolution when compared with the model GAL regulon of Saccharomyces cerevisiae. The Gal4 transcription factor is a positive regulator of gene expression of galactose-induced genes. This protein represents a large fungal family of transcription factors, Gal4 family, which includes over 50 members in the yeast Saccharomyces cerevisiae .